There is a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors from the dorsal horn to minimize afferent discomfort transmission and produce analgesia. Thus, medicine like clonidine that goal alpha-2 receptors can affect the transmission of agony. Applies to clonidine: oral pill, oral tablet https://yxzbookmarks.com/story19745678/onolidine-fundamentals-explained