While in the LSD-bound crystal framework, the facet chain of your lid residue L209EL2 types intensive hydrophobic contacts with the two LSD and bordering residues in TMs III, IV, and V (Determine 4C). Once the lid moved apart to expose the binding pocket in simulation, several of such contacts broke. https://hylistings.com/story20796211/lsd-crystal-can-be-fun-for-anyone